Brimonidine Tartrate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Brimonidine Tartrate 是一种高选择性 α-肾上腺素能受体激动剂，对 α2A 肾上腺素受体的 EC50 为 0.45 nM，用于治疗开角型青光眼或高眼压症。

Brimonidine Tartrate is a highly selective α-adrenergic receptor agonist with EC50 of 0.45 nM for the α2A adrenoreceptor, and used to treat open-angle glaucoma or ocular hypertension.(In Vitro):[3H]Brimonidine (UK 14304) is a full agonist at alpha 2-adrenergic receptors. [3H]Brimonidine (UK 14304) labels at least 2 specific binding sites in human brain that both have the characteristics of an alpha 2-adrenergic binding site. GTP decreases agonist binding at both of these sites, but with different potencies at each site.

[3H]Brimonidine (UK 14304) is a full agonist at alpha 2-adrenergic receptors. [3H]Brimonidine (UK 14304) labels at least 2 specific binding sites in human brain that both have the characteristics of an alpha 2-adrenergic binding site. GTP decreases agonist binding at both of these sites, but with different potencies at each site [1-3].

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AGN 190342LF | Alphagan P

Endocrinology/Hormones

Adrenergic Receptor

α2A-adrenergic receptor

Other Indications

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70359-46-5

442.22

C15H16BrN5O6

>98% (HPLC)

Water: 75 mg/mL (169.59 mM); DMSO: 88 mg/mL (198.99 mM)

C1CN=C(N1)NC2=C(C3=NC=CN=C3C=C2)Br.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O

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(-20℃)

With Ice Pack

≥ 2 years